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Developed pressure data may provide misinformation when used alone to evaluate systolic function in isovolumetric left ventricle preparations BJMBR
Murad,N.; Tucci,P.J.F..
We report data showing that developed pressure (DPmax) may lead to opposite conclusion with respect to maximal developed circumferential wall stress (<FONT FACE="Symbol">s</FONT>max) when used to assess contractile function in left ventricle isovolumic preparations. Isovolumetric left ventricle preparations of rats with cardiac hypertrophy (H; N = 10) induced by isoproterenol administration showed higher DPmax (174 ± 14 mmHg) than control (C; N = 8) animals (155 ± 12 mmHg) or rats with regression (R; N = 8) of hypertrophy (144 ± 11 mmHg). In contrast, the estimated <FONT FACE="Symbol">s</FONT>max for C (145 ± 26 kdynes/cm2) and R (133 ± 17 kdynes/cm2) was higher than for H (110 ± 13 kdynes/cm2). According to Laplace's law, the...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Contractile function; Developed pressure; Wall stress; Cardiac hypertrophy; Laplace's law.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600014
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IL-6 and TNF-α serum levels are associated with early death in community-acquired pneumonia patients BJMBR
Bacci,M.R.; Leme,R.C.P.; Zing,N.P.C.; Murad,N.; Adami,F.; Hinnig,P.F.; Feder,D.; Chagas,A.C.P.; Fonseca,F.L.A..
Community-acquired pneumonia (CAP) is amongst the leading causes of death worldwide. As inflammatory markers, cytokines can predict outcomes, if interpreted together with clinical data and scoring systems such as CURB-65, CRB, and Acute Physiology and Chronic Health Evaluation II (APACHE II). The aim of this study was to determine the impact of inflammatory biomarkers on the early mortality of hospitalized CAP patients. Twenty-seven CAP patients needing hospitalization were enrolled for the study and samples of interleukin-1 (IL-1) and interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), and homocystein were collected at the time of admission (day 1) as well as on the seventh day of the treatment. There was a significant...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Community acquired pneumonia; Interleukin-6; Tumor necrosis factor α; Sepsis.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000500427
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Performance of two-dimensional Doppler echocardiography for the assessment of infarct size and left ventricular function in rats BJMBR
Nozawa,E.; Kanashiro,R.M.; Murad,N.; Carvalho,A.C.C.; Cravo,S.L.D.; Campos,O.; Tucci,P.J.F.; Moises,V.A..
Although echocardiography has been used in rats, few studies have determined its efficacy for estimating myocardial infarct size. Our objective was to estimate the myocardial infarct size, and to evaluate anatomic and functional variables of the left ventricle. Myocardial infarction was produced in 43 female Wistar rats by ligature of the left coronary artery. Echocardiography was performed 5 weeks later to measure left ventricular diameter and transverse area (mean of 3 transverse planes), infarct size (percentage of the arc with infarct on 3 transverse planes), systolic function by the change in fractional area, and diastolic function by mitral inflow parameters. The histologic measurement of myocardial infarction size was similar to the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rats; Myocardial infarction size; Systolic and diastolic function; Doppler echocardiography.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500016
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